Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis
Our findings enrich the understanding of the regulatory mechanisms underlying macrophage polarization in gouty arthritis and highlight the potential applications of probiotics and their metabolites in clinical gout treatment.
Authors
- Y. P. Guo (ORCID: https://orcid.org/0009-0006-4829-4185)
- Moqi Fan
- Tiejuan Shao (ORCID: https://orcid.org/0000-0002-7644-8130)
- Chengping Wen (ORCID: https://orcid.org/0000-0001-9254-6235)
- Kejian Shi (ORCID: https://orcid.org/0000-0003-1396-7424)
- Yu Lou (ORCID: https://orcid.org/0009-0007-1343-6064)
- Lin Huang (ORCID: https://orcid.org/0000-0002-8036-8408)
- F. Chen (ORCID: https://orcid.org/0000-0002-5764-4670)
- Siyue Song (ORCID: https://orcid.org/0000-0002-0508-5205)
- Jialu Wang (ORCID: https://orcid.org/0009-0002-4866-4706)
- Jiatao Li
- Xianghui Wen
Institutions
- Zhejiang Chinese Medical University (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1016/j.jare.2025.05.036
- Citations
- 11
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 15.74
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province