Effectiveness of Recombinant Human Bone Morphogenetic Protein‐2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP‐2 TRIAL)
This study demonstrated that rhBMP-2 coated BCP significantly enhanced early graft substitution in socket preservation sites compared to BCP alone. There was a significantly higher percentage of new bone formation in the rhBMP-2/BCP group both at 6 and 9 months. Additionally, the rhBMP-2/BCP group exhibited faster resorption of the graft material and earlier maturation of newly formed bone. These findings strongly suggest that rhBMP-2/BCP can be an effective treatment modality for socket preservation, promoting predictable and accelerated bone regeneration.
Authors
- Harjeet Singh (ORCID: https://orcid.org/0009-0004-9562-8032)
- Delfin Lovelina Francis (ORCID: https://orcid.org/0000-0002-3355-1322)
- Shaswata Karmakar (ORCID: https://orcid.org/0000-0002-7172-0369)
- Rahul Sakla
- Saravanan Sampoornam Pape Reddy (ORCID: https://orcid.org/0000-0003-1391-6125)
- Shaili Pradhan (ORCID: https://orcid.org/0000-0003-4708-8209)
- Manish Rathi (ORCID: https://orcid.org/0000-0002-7689-2506)
- Harshini Thirumoorthi (ORCID: https://orcid.org/0009-0007-1373-968X)
Institutions
- Manipal Academy of Higher Education (IN)
- Indian Army (IN)
- Arunai Engineering College (IN)
- Kathmandu Medical College Teaching Hospital (NP)
- Saveetha University (IN)
Publication Details
- Journal
- Clinical and Experimental Dental Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/cre2.70134
- Citations
- 3
- Primary Topic
- Dental Implant Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 5.37