Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration
Tendon injury occurs at high frequency and is difficult to repair. Identification of human stem cells being able to regenerate tendon will greatly facilitate the development of regenerative medicine for tendon injury. Genetic and functional analyses identify human CD29+/CD56+ myogenic progenitors with tenogenic differentiation potential in vitro and in vivo. Transplantation of human CD29+/CD56+ myogenic progenitors contributes to injured tendon repair and thus improves locomotor function. Interestingly, the tendon differentiation potential in mouse muscle stem cells is minimal and the higher TGFβ signaling level may be the key for the distinct feature of human CD29+/CD56+ myogenic progenitors. The discovery of bi-potential CD29+/CD56+ myogenic progenitors highlights their potential as a novel adult stem cell source for tendon regeneration.
Authors
- Lili Han (ORCID: https://orcid.org/0000-0002-8105-1672)
- Minghui Wang (ORCID: https://orcid.org/0000-0002-4993-6606)
- Zhanghua Li (ORCID: https://orcid.org/0000-0002-9919-8111)
- Xingzuan Lin (ORCID: https://orcid.org/0009-0006-6063-666X)
- Shenao Zhou (ORCID: https://orcid.org/0009-0002-6582-9592)
- Xiexiang Shao (ORCID: https://orcid.org/0000-0003-4837-1305)
- Siyuan Zhu (ORCID: https://orcid.org/0000-0002-0470-2523)
- Sheng Li (ORCID: https://orcid.org/0000-0002-6258-3147)
- Jianhua Wang (ORCID: https://orcid.org/0000-0001-6831-9593)
- Wenjun Yang (ORCID: https://orcid.org/0000-0003-3548-0174)
- Xin Fu (ORCID: https://orcid.org/0000-0001-8473-5079)
- Hao Zhou (ORCID: https://orcid.org/0000-0001-5188-9899)
- Ping Hu
Institutions
- Fujian Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- XinHua Hospital (CN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Tongren Hospital (CN)
- Center for Excellence in Molecular Cell Science (CN)
- Wuhan Third Hospital (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- eLife
- Published
- 2025-05-19
- DOI
- https://doi.org/10.7554/elife.98636.3
- Citations
- 1
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Natural Science Foundation of China