JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway
Our findings unveil a novel function of JAM-C in preventing ocular fibrosis by inhibiting the TAZ/KLF6 pathway, and suggest new therapeutic possibilities for the treatment of fibrotic diseases.
Authors
- Min Chen (ORCID: https://orcid.org/0000-0003-4234-3178)
- Ying Guo (ORCID: https://orcid.org/0000-0002-5199-8128)
- Yuanlong Zhao
- Guanqun Huang
- Xiaoling Zeng (ORCID: https://orcid.org/0000-0003-2953-9520)
- Weisi Lu (ORCID: https://orcid.org/0000-0001-6039-6009)
- Xuri Li (ORCID: https://orcid.org/0000-0002-8277-0767)
- Wanhong Li
- Haiqing Kuang
- Yihan Zhang (ORCID: https://orcid.org/0000-0003-1566-5972)
- Ying Li (ORCID: https://orcid.org/0000-0001-9560-2212)
- Xiaolu Wang (ORCID: https://orcid.org/0000-0003-2229-9050)
- Jing Qin (ORCID: https://orcid.org/0000-0002-7059-0929)
- Lijuan Huang (ORCID: https://orcid.org/0000-0002-8713-2641)
- Yuxiang Du (ORCID: https://orcid.org/0009-0005-0725-0939)
- Guangli Sun (ORCID: https://orcid.org/0000-0002-4240-4586)
- Shasha Wang
Institutions
- Sun Yat-sen University (CN)
- Wuhan University (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Wuxi People's Hospital (CN)
- Jining Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1016/j.jare.2025.05.037
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00