N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells
Transcripts with higher m<sup>6</sup>A levels in the 3'UTR region were less abundant, and vice versa. However, changes in mRNA levels of the target genes didn't impact their corresponding protein levels or NK cell functionality.
Authors
- Mohamed Z. Gad (ORCID: https://orcid.org/0000-0003-1173-8628)
- Khaled Abou‐Aisha
- Carsten Watzl (ORCID: https://orcid.org/0000-0001-5195-0995)
- Doris Urlaub
- Mona Rady (ORCID: https://orcid.org/0000-0002-7561-853X)
- Mina Sandusky
- Raghda A. Elsabbagh
- Ola Khorshid (ORCID: https://orcid.org/0000-0002-2693-5547)
- Ghada Abdelhady
Institutions
- Cairo University (EG)
- TU Dortmund University (DE)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- German University in Cairo (EG)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s12920-025-02147-y
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Leibniz-Institut für Arbeitsforschung an der TU Dortmund
- Deutscher Akademischer Austauschdienst
- Leibniz-Gemeinschaft