Longitudinal assessment of COVID-19 vaccine immunogenicity in people with HIV stratified by CD4+ T-cell count in the Netherlands: A two-year follow-up study
Long-term humoral responses were lower in PWH with a CD4+ T-cell count < 200 cells per µL compared to those with a CD4+ T-cell count ≥ 200 cells per µL. National COVID-19 vaccine guidelines recommending booster vaccines for all PWH, should therefore specifically emphasise the need for booster vaccines in those with a CD4+ T-cell count < 200 cells per µL. Trial registration: The trial was registered on the International Clinical Trials Platform (registration number: EUCTR2021-001054-57-N).
Authors
- Anna H.E. Roukens (ORCID: https://orcid.org/0000-0002-1397-0992)
- Susanne Bogers (ORCID: https://orcid.org/0000-0002-8212-2946)
- Rory D. de Vries (ORCID: https://orcid.org/0000-0003-2817-0127)
- Corine H. GeurtsvanKessel (ORCID: https://orcid.org/0000-0002-7678-314X)
- Casper Rokx (ORCID: https://orcid.org/0000-0002-1904-6450)
- Kathryn S. Hensley (ORCID: https://orcid.org/0000-0003-1675-2445)
- Bart J. A. Rijnders (ORCID: https://orcid.org/0000-0003-3343-9610)
- Kees Brinkman (ORCID: https://orcid.org/0009-0005-4791-1279)
- Marlou J. Jongkees (ORCID: https://orcid.org/0000-0002-9589-7281)
- Pedro Miranda Afonso (ORCID: https://orcid.org/0000-0001-6708-9597)
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- OLVG (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1371/journal.pone.0323792
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universiteit Leiden
- ZonMw
- Stichting HIV Monitoring