Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study

PA-BSI in IMWs is characterized by a relatively low incidence of septic shock and rate of resistance, alongside high rates of appropriate empiric therapy. Despite these favorable factors, meropenem may represent a valuable therapeutic option for PA-BSI with severe presentations in this setting since mortality remains substantial (22.5%). Our findings underscore the critical importance of early source control and identify septic shock as a key predictor of mortality even in the setting of IMW. The proposed bedside nomogram model could empower clinicians to identify high-risk patients early, facilitating timely interventions and improving outcomes in this vulnerable population.

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Publication Details

Journal
PLoS ONE
Published
2025-05-19
DOI
https://doi.org/10.1371/journal.pone.0317540
Citations
2
Primary Topic
Antibiotic Use and Resistance
Type
article
Field-Weighted Citation Impact
2.52
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article

Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study

Vincenzo Scaglione, Eleonora Taddei, Maura Sanino, Małgorzata Mikulska et al.
2 citations
PLoS ONE
Antibiotic Use and Resistance
2.52
article

Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study

Vincenzo Scaglione, Eleonora Taddei, Maura Sanino, Małgorzata Mikulska, Nicholas Geremia, Emanuele Pivetta, Renato Pascale, Veronica Vassia, Silvia Corcione, Matteo Bassetti, Davide Fiore Bavaro, Pierluigi Viale, Nour Shbaklo, Simone Mornese Pinna, Maddalena Giannella, Francesco Giuseppe De Rosa, Daniele Roberto Giacobbe, Antonio Vena, Francesca Giovannenze, Michele Bartoletti, Benedetta Fumarola, Michela Schenone
article en
2 citations

Abstract

PA-BSI in IMWs is characterized by a relatively low incidence of septic shock and rate of resistance, alongside high rates of appropriate empiric therapy. Despite these favorable factors, meropenem may represent a valuable therapeutic option for PA-BSI with severe presentations in this setting since mortality remains substantial (22.5%). Our findings underscore the critical importance of early source control and identify septic shock as a key predictor of mortality even in the setting of IMW. The proposed bedside nomogram model could empower clinicians to identify high-risk patients early, facilitating timely interventions and improving outcomes in this vulnerable population.

PLoS ONEVol. 20(5)
Tufts University (US), AOL (United States) (US), Humanitas University (IT), University of Padua (IT), Agostino Gemelli University Polyclinic (IT), IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT), Ospedale Civile Di Ivrea (IT), Ospedale San Paolo (IT), Department of Medical Sciences (BY), A. O. Ordine Mauriziano di Torino (IT), Ospedale dell' Angelo (IT), Ospedale Policlinico San Martino (IT), Hospital for Tropical Diseases (VN), IRCCS Humanitas Research Hospital (IT), University of Turin (IT), University of Brescia (IT), University of Genoa (IT), University of Bologna (IT)
Good health and well-being
Openalex Percentile: Top 11%
Antibiotic Use and Resistance
2.52
DOIOpen Access PDFOpenAlex
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