Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)
The tumor tissue alteration of interest was detected in the plasma of 81% of patients who were enrolled in the NCI-MATCH trial based on central tissue testing and had contemporaneous tissue and plasma samples. This suggests a potential role for liquid biopsy in patient enrollment in trials evaluating biomarker-driven anticancer therapies. See related commentary by Russo et al., p. 4217.
Authors
- Keyur P. Patel (ORCID: https://orcid.org/0000-0001-5081-2427)
- Jeffrey Sklar (ORCID: https://orcid.org/0000-0001-5334-6070)
- Ying Yuan (ORCID: https://orcid.org/0000-0003-3163-480X)
- Lyndsay N. Harris (ORCID: https://orcid.org/0000-0002-9774-6719)
- Keith T. Flaherty (ORCID: https://orcid.org/0000-0002-3402-0478)
- Peter James O'Dwyer (ORCID: https://orcid.org/0000-0002-9302-4073)
- Carlos L. Arteaga (ORCID: https://orcid.org/0000-0003-0870-9586)
- Alice P. Chen (ORCID: https://orcid.org/0000-0002-1426-853X)
- Mark J. Routbort (ORCID: https://orcid.org/0000-0003-4860-261X)
- Richard F. Little (ORCID: https://orcid.org/0000-0002-4091-1699)
- A. John Iafrate (ORCID: https://orcid.org/0000-0002-7888-4067)
- Leylah Drusbosky (ORCID: https://orcid.org/0000-0002-9401-4600)
- Mohamed A. Gouda (ORCID: https://orcid.org/0000-0003-4829-6739)
- Filip Jankú (ORCID: https://orcid.org/0000-0002-8123-4065)
- Brent D. Coffey (ORCID: https://orcid.org/0009-0009-2047-5699)
- Funda Meric‐Bernstam (ORCID: https://orcid.org/0000-0001-6816-6072)
- Xiaofeng Zheng
- James V. Tricoli (ORCID: https://orcid.org/0000-0003-3975-8516)
- Stanley R. Hamilton (ORCID: https://orcid.org/0000-0002-8331-1052)
- P. Mickey Williams (ORCID: https://orcid.org/0000-0002-3309-5988)
Institutions
- City Of Hope National Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Yale University (US)
- University of New Haven (US)
- Massachusetts General Hospital (US)
- Guardant (United States) (US)
- City of Hope (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3531
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.81