β-Selective Addition of Pyrroles to Electron-Deficient Alkenes in Both Catalytic and Stoichiometric Modes on B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>
To the best of our knowledge, the addition of pyrroles to electron-deficient alkenes (APEda) via electrophilic aromatic substitution (S<sub>E</sub>Ar) has been reported to occur exclusively at the α-position of the pyrrole without any formation, even in trace amounts, of a β-adduct, β-<b>3</b>. In sharp contrast to the prolonged immutable observation, we established an original S<sub>E</sub>Ar-based APEda (S<sub>E</sub>Ar-APEda) system applicable to both the catalytic and stoichiometric synthesis of β-<b>3</b>.
Authors
- Takaaki Sonoda (ORCID: https://orcid.org/0000-0001-8075-9495)
- Mitsuyasu Kawakami
- Akira Ono (ORCID: https://orcid.org/0000-0002-2150-7084)
- Teruhisa Tsuchimoto (ORCID: https://orcid.org/0000-0002-3780-8439)
- Shinichi Sekine
- Miho Kashiwa
Institutions
- Meiji University (JP)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1021/acsomega.5c00371
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Meiji University