Primary Lateral Sclerosis
Our findings suggest that a diagnosis of PLS should be deferred until 4 years after symptom onset because shorter durations correlate with higher ALS conversion rates and shorter survival. Categorization by regional involvement may facilitate more effective monitoring of patients with UMN syndromes.
Authors
- F. Brugman
- Philip Van Damme (ORCID: https://orcid.org/0000-0002-4010-2357)
- Bálint S. de Vries
- Eva Maria Johanna de Boer (ORCID: https://orcid.org/0000-0002-2629-2748)
- Jan H. Veldink (ORCID: https://orcid.org/0000-0001-5572-9657)
- Leonard H. van den Berg (ORCID: https://orcid.org/0000-0002-6559-3965)
- Michael A. van Es (ORCID: https://orcid.org/0000-0002-7709-5883)
Institutions
- Allen Institute for Brain Science (US)
- University Medical Center Utrecht (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Neurology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1212/wnl.0000000000213461
- Citations
- 5
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 6.95