Transcription factor ZNF266 suppresses cancer progression by modulating CA9-mediated intracellular pH alteration in lung adenocarcinoma
Our study demonstrated that ZNF266 inhibits LUAD progression in a pH-dependent manner via modulating CA9 expression, uncovering its therapeutic significance for LUAD treatment.
Authors
- Han Lin (ORCID: https://orcid.org/0000-0003-1663-5468)
- Guangyao Shan (ORCID: https://orcid.org/0000-0002-2993-5817)
- Di Ge (ORCID: https://orcid.org/0000-0003-4568-7830)
- Guoshu Bi (ORCID: https://orcid.org/0000-0003-2187-5271)
- Yunyi Bian (ORCID: https://orcid.org/0000-0003-3864-1199)
- Haochun Shi (ORCID: https://orcid.org/0009-0009-3471-0901)
- Jiaqi Liang (ORCID: https://orcid.org/0000-0002-4738-4238)
- Xiaolong Huang (ORCID: https://orcid.org/0000-0003-4727-6090)
- Cheng Zhan (ORCID: https://orcid.org/0000-0001-8745-9276)
- Huiqin Yang
- Junkan Zhu
- Shencheng Ren
- Binyang Pan
- Guangyin Zhao
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s12931-025-03278-7
- Citations
- 2
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation