Small Nuclear Ribonucleoprotein Autoantibody Associated With Blood-Nerve Barrier Breakdown in Guillain-Barré Syndrome
U1-snRNP autoantibodies are associated with the breakdown of BNB in GBS, through the reduction of U1-snRNP and claudin-5 and the induction of NF-κB activation in BNB-endothelial cells. A temporary autoantibody response against snRNP may be boosted by the periodic response to infection in GBS.
Authors
- Michiaki Koga (ORCID: https://orcid.org/0000-0002-1356-955X)
- Masayuki Nakamori (ORCID: https://orcid.org/0000-0003-4714-3044)
- Fumitaka Shimizu (ORCID: https://orcid.org/0000-0003-4163-2939)
- Toshihiko Maeda
- Yoichi Mizukami (ORCID: https://orcid.org/0000-0002-3290-0754)
- Kenji Watanabe (ORCID: https://orcid.org/0000-0002-5069-1706)
- Yukio Takeshita (ORCID: https://orcid.org/0000-0002-0314-550X)
- Ryota Sato (ORCID: https://orcid.org/0000-0001-6405-5367)
- Takashi Kanda (ORCID: https://orcid.org/0000-0001-8919-6377)
Institutions
- Yamaguchi University (JP)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1212/nxi.0000000000200405
- Citations
- 2
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.78