Dual Photoredox/Copper-Catalyzed Radical <i>cis</i>-Selective Allylic Trifluoromethylation
We herein report a dual visible-light photoredox- and copper-catalyzed <i>Z</i>-selective allyl trifluoromethylation reaction of allylamine by using trifluoromethylpyridinium salt (TFSP) as the trifluoromethyl radical precursor. Various thermodynamically disfavorable allyl trifluoromethylated <i>cis</i>-enamides were accessible with moderate to good isolated yields. Cuprous oxide or copper nanoclusters were crucial as the co-catalyst for this transformation.
Authors
- Shaoqun Zhu (ORCID: https://orcid.org/0000-0003-2639-4098)
- Qiu Sun (ORCID: https://orcid.org/0000-0003-3345-3391)
- Hong Hou (ORCID: https://orcid.org/0000-0002-9103-9888)
- Xiao Yun Chen (ORCID: https://orcid.org/0000-0002-0443-1305)
- Huaguang Yu (ORCID: https://orcid.org/0000-0002-5744-947X)
- Changhao Yan (ORCID: https://orcid.org/0000-0002-8936-3945)
- Ying Han (ORCID: https://orcid.org/0000-0002-2424-5163)
- Yan Ren (ORCID: https://orcid.org/0000-0002-1421-8487)
- Chengjun Chen
- Xiaoyu Shen (ORCID: https://orcid.org/0009-0007-6963-9979)
Institutions
- Jianghan University (CN)
- Jiangsu University of Science and Technology (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1021/acs.joc.5c00848
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- National Natural Science Foundation of China