Iron-Catalyzed Alkylative Aminosulfonylation of Alkenes and Alkynes via Radical-Anion Relay
A novel Fe-catalyzed alkylative aminosulfonylation of alkenes and alkynes with alkyl halides and O-Ts activated hydroxylamines by using Na<sub>2</sub>S<sub>2</sub>O<sub>4</sub> as a reductant and sulfone source has been developed. The metal-electron-shuttle catalysis was discovered to be vital for the highly efficient generation of sulfonyl radicals and anions without requiring organometallic intermediates. This method provides efficient access to sulfonamides from easily available alkenes and Na<sub>2</sub>S<sub>2</sub>O<sub>4</sub> and features a broad substrate scope.
Authors
- Bangkui Yu (ORCID: https://orcid.org/0009-0004-0013-396X)
- Xiaoya Hou (ORCID: https://orcid.org/0000-0002-7682-5397)
- Hanmin Huang (ORCID: https://orcid.org/0000-0002-0108-6542)
Institutions
- University of Science and Technology of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1021/acs.orglett.5c01171
- Citations
- 4
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Key Technologies Research and Development Program