Exploring Sex Differences in Type 2 Diabetes via a Male-Dominant Beta-Cell Cluster from Single-Cell Pancreatic Sequencing of Public Datasets
We have identified a male-dominant beta-cell cluster characterized by distinct gene expression, signaling pathways, and cell interactions. These findings provide insights into the pathophysiology of type 2 diabetes and may inform the development of more effective, sex-specific therapeutic strategies in the future.
Authors
- Samel Park (ORCID: https://orcid.org/0000-0002-5717-0743)
- Hyo‐Wook Gil (ORCID: https://orcid.org/0000-0003-2550-2739)
- Seongho Ryu (ORCID: https://orcid.org/0000-0001-9697-7972)
- Nguyễn Vân Anh
Institutions
- Soonchunhyang University (KR)
Publication Details
- Journal
- Endocrinology and Metabolism
- Published
- 2025-05-19
- DOI
- https://doi.org/10.3803/enm.2025.2297
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Research Foundation
- Soonchunhyang University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea