Ketogenic diet and β-hydroxybutyrate inhibit HDAC1 to preserve vascular smooth muscle cell function in thoracic aortic aneurysm
Our study reveals the important roles of KD and BHB in regulating HDAC1, preserving mitochondrial function, maintaining VSMC phenotype, and reducing oxidative stress in TAA. Our findings demonstrate KD and BHB as promising therapeutic strategies for treating TAA by targeting specific molecular pathways involved in its progression. This study highlights the significance and innovation of lifestyle interventions, such as KD, in mitigating TAA by addressing its underlying molecular mechanisms.
Authors
- Aijun Sun (ORCID: https://orcid.org/0000-0003-1488-0937)
- Liwei Liu (ORCID: https://orcid.org/0000-0001-5884-7333)
- Jing Yang (ORCID: https://orcid.org/0000-0003-0773-494X)
- Lihong Pan (ORCID: https://orcid.org/0000-0002-1995-2373)
- Zhen Dong (ORCID: https://orcid.org/0000-0003-3108-0245)
- Zhiqiang Pei (ORCID: https://orcid.org/0000-0001-5127-3509)
- Xinyu Weng (ORCID: https://orcid.org/0000-0002-7620-0813)
- Luo W (ORCID: https://orcid.org/0000-0003-0630-637X)
- Xiurui Ma
- Hongdong Su
- Pingjin Gao (ORCID: https://orcid.org/0000-0002-7750-3314)
Institutions
- Shanghai Medical College of Fudan University (CN)
- University of Shanghai for Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- Shanghai Xuhui Central Hospital (CN)
- Beijing Anzhen Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai Institute of Hypertension (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1016/j.jare.2025.05.035
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33