Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice
These findings provide clinically relevant insights into the seizure type-specific effects of hippocampal LFS, which, alongside synaptic and behavioural improvements, could contribute to enhanced seizure control and quality of life in MTLE patients.
Authors
- Andrea Djie-Maletz
- Andreas Vlachos (ORCID: https://orcid.org/0000-0002-2646-3770)
- Enya Paschen (ORCID: https://orcid.org/0000-0001-6323-3889)
- Ute Häussler (ORCID: https://orcid.org/0000-0001-5601-9833)
- Piret Kleis (ORCID: https://orcid.org/0000-0001-9247-8842)
- Carola A. Haas (ORCID: https://orcid.org/0000-0002-7022-4136)
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Bernstein Center for Computational Neuroscience Freiburg (DE)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1016/j.nbd.2025.106965
- Citations
- 2
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Deutsche Forschungsgemeinschaft