Ascorbate for Organ Dysfunction in Critically Ill Patients With Sepsis
Ascorbate did not improve days free of organ failure, although no safety concerns were identified in this small study. Ascorbate was shown to reduce a biological marker of inflammation associated with adverse outcomes in sepsis and lung injury.
Authors
- Bruce Thompson (ORCID: https://orcid.org/0000-0002-5885-0652)
- Andrew Goodwin (ORCID: https://orcid.org/0000-0002-6543-9458)
- Chadwick D. Miller (ORCID: https://orcid.org/0000-0002-4362-4409)
- Gregory W. Hendey (ORCID: https://orcid.org/0000-0002-0170-8743)
- Mark Tidswell (ORCID: https://orcid.org/0000-0001-6333-6810)
- Abhijit Duggal (ORCID: https://orcid.org/0000-0003-4220-2359)
- Richard R. Riker (ORCID: https://orcid.org/0000-0002-0682-6204)
- Lorraine B. Ware (ORCID: https://orcid.org/0000-0002-9429-4702)
- Andrea S. Foulkes (ORCID: https://orcid.org/0000-0002-9520-0501)
- Adit A. Ginde (ORCID: https://orcid.org/0000-0003-2325-206X)
- Ari Moskowitz (ORCID: https://orcid.org/0009-0003-5223-3121)
- Neil R. Aggarwal (ORCID: https://orcid.org/0000-0002-0922-8824)
- Roy G. Brower
- Wesley H. Self (ORCID: https://orcid.org/0000-0002-9300-3045)
- Kevin W. Gibbs (ORCID: https://orcid.org/0000-0002-5272-2289)
- R. Duncan Hite (ORCID: https://orcid.org/0000-0002-2625-8750)
- Catherine L. Hough (ORCID: https://orcid.org/0000-0001-6425-0867)
- Bryce R. H. Robinson
- Michael A. Matthay (ORCID: https://orcid.org/0000-0003-3039-8155)
- Kathryn A. Hibbert (ORCID: https://orcid.org/0000-0001-7908-5446)
- D. Clark Files
- Steven Y. Chang (ORCID: https://orcid.org/0000-0002-7365-5265)
- Scott Fields
- Kathleen D. Liu (ORCID: https://orcid.org/0000-0003-4891-8649)
- Akram Khan (ORCID: https://orcid.org/0000-0003-3091-632X)
- Alpha A. Fowler (ORCID: https://orcid.org/0000-0002-1445-8800)
- Samuel Morris Brown (ORCID: https://orcid.org/0000-0003-1206-6261)
- Weixing Huang (ORCID: https://orcid.org/0009-0009-5279-394X)
- Ivor S. Douglas (ORCID: https://orcid.org/0000-0002-4541-1431)
- Poying Lai
- Donald M. Yealy
- Estelle S. Harris
Institutions
- Johns Hopkins University (US)
- University of California System (US)
Publication Details
- Journal
- CHEST Critical Care
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1016/j.chstcc.2025.100168
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases