Exosomes Derived From Human Gingival Mesenchymal Stem Cells Induce Metabolic Reprogramming of Inflammatory Macrophages
By inhibiting the activation of HIF-1α signalling pathway, GMSC-Exo trigger metabolic reprogramming in macrophages, thereby regulating the macrophage transformation from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype. This change enhances the local inflammatory environment, aiding tissue repair and regeneration.
Authors
- Jingshu Yang
- Quanchen Xu (ORCID: https://orcid.org/0000-0003-0484-0878)
- Chun Fan (ORCID: https://orcid.org/0000-0002-7691-172X)
- Lubin Liu (ORCID: https://orcid.org/0000-0002-5718-2541)
- Yingzhe Hu (ORCID: https://orcid.org/0000-0002-3810-883X)
- Ye Liu (ORCID: https://orcid.org/0000-0001-5827-5240)
- Zhiguo Wang (ORCID: https://orcid.org/0000-0003-4401-4079)
- Jialu Wang (ORCID: https://orcid.org/0009-0002-4866-4706)
- Yutong Xie
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/jcpe.14184
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China