Harnessing phage consortia to mitigate the soil antibiotic resistome by targeting keystone taxa Streptomyces
Our study demonstrates that some bacterial keystone taxa are critical for ARG maintenance and dissemination in soil microbiomes, and opens new ecological avenues for microbiome modification and resistome control. This study advances our understanding of how metagenomics-informed phage consortia can be used to predictably regulate soil microbiome composition and functioning by targeting keystone bacterial taxa. Video Abstract.
Authors
- Hanpeng Liao (ORCID: https://orcid.org/0000-0001-7539-2668)
- Ling Jin (ORCID: https://orcid.org/0000-0003-1267-7396)
- Pingfeng Yu (ORCID: https://orcid.org/0000-0003-0402-773X)
- Dan Huang (ORCID: https://orcid.org/0000-0003-3216-7916)
- Qian Du (ORCID: https://orcid.org/0000-0001-7438-9838)
- Tian Gao (ORCID: https://orcid.org/0000-0002-0375-4073)
- Chang Wen
- Ville‐Petri Friman (ORCID: https://orcid.org/0000-0002-1592-157X)
- Pedro J. J. Alvarez (ORCID: https://orcid.org/0000-0002-6725-7199)
- Mengting Yuan (ORCID: https://orcid.org/0000-0003-0017-3908)
- Feng Ju (ORCID: https://orcid.org/0000-0003-4137-5928)
- Qiue Yang (ORCID: https://orcid.org/0000-0002-0552-7763)
- Chen Liu (ORCID: https://orcid.org/0009-0003-0430-6146)
- Xiang Tang (ORCID: https://orcid.org/0000-0001-6764-3447)
- Shungui Zhou
Institutions
- University of Helsinki (FI)
- Hong Kong Polytechnic University (HK)
- Westlake University (CN)
- Fujian Agriculture and Forestry University (CN)
- Rice University (US)
- Zhejiang University (CN)
- University of California, Berkeley (US)
Publication Details
- Journal
- Microbiome
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s40168-025-02117-7
- Citations
- 8
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 13.73
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China