Validation of dietary whey protein substrate challenge absorption test as an indicator of proteolysis
In EPI pigs, measurement of peptide-derived amino acids following a meal with whey substrate differentiates the activity of aspergillus protease compared to no enzyme and the 75 mg dose was superior to pancrelipase. The evidence presented here in EPI pigs demonstrates that the whey substrate absorption challenge test reflects the proteolytic activity of different doses of exogenous pancreatic proteases.
Authors
- Steven D. Freedman
- Kamil Zaworski (ORCID: https://orcid.org/0000-0003-4538-3159)
- Drucy Borowitz (ORCID: https://orcid.org/0000-0003-3685-4078)
- Meghana Sathe
- Kateryna Pierzynowska (ORCID: https://orcid.org/0000-0002-3290-339X)
- Stefan Pierzynowski (ORCID: https://orcid.org/0000-0002-0308-3214)
- R. Gallotto (ORCID: https://orcid.org/0000-0002-8961-2075)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Lund University (SE)
- Kielanowski Institute of Animal Physiology and Nutrition (PL)
- Instytut Medycyny Wsi im. Witolda Chodźki (PL)
- Beam Therapeutics (United States) (US)
- University at Buffalo, State University of New York (US)
- Trelleborg (Sweden) (SE)
- The University of Texas Southwestern Medical Center (US)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1371/journal.pone.0323730
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02