Cytoplasmic HMGB1 promotes the activation of JAK2-STAT3 signaling and PD-L1 expression in breast cancer
These findings underscore the critical role of intracellular HMGB1 in modulating PD-L1 expression via the JAK2-STAT3 signaling pathways in breast cancer and suggest that targeting HMGB1 translocation is a promising strategy for breast cancer treatment.
Authors
- Jeon‐Soo Shin (ORCID: https://orcid.org/0000-0002-8294-3234)
- Ju‐Young Han
- Woo Joong Rhee (ORCID: https://orcid.org/0000-0001-9690-0553)
Institutions
- Yonsei University (KR)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s10020-025-01235-0
- Citations
- 4
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 5.27
Funders
- National Research Foundation
- Yonsei University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Institute for Basic Science
- Yonsei University College of Medicine