Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies
Our study provides a reliable strategy for the large-scale generation of fratricide-resistant CD7 CAR-iNK cells with robust anti-tumor effects from hPSCs, offering a promising cell product to treat T-cell malignancies.
Authors
- Qitong Weng (ORCID: https://orcid.org/0009-0003-3929-4384)
- Xiujuan Zheng (ORCID: https://orcid.org/0000-0002-4703-9530)
- Jingliao Zhang (ORCID: https://orcid.org/0000-0003-2962-9884)
- Dehao Huang (ORCID: https://orcid.org/0009-0006-2693-9309)
- Chenyuan Zhang (ORCID: https://orcid.org/0000-0001-6298-8358)
- Mengyun Zhang (ORCID: https://orcid.org/0000-0003-1505-3757)
- Leqiang Zhang (ORCID: https://orcid.org/0000-0003-1439-1287)
- Ziyun Xiao
- Chengxiang Xia (ORCID: https://orcid.org/0000-0002-7923-2802)
- Yunqing Lin (ORCID: https://orcid.org/0000-0002-6743-954X)
- Yao Wang (ORCID: https://orcid.org/0000-0003-4432-1335)
- Lijuan Liu (ORCID: https://orcid.org/0000-0002-7906-6277)
- Fan Zhang (ORCID: https://orcid.org/0000-0003-4692-0526)
- Yi Chen (ORCID: https://orcid.org/0000-0002-8298-0350)
- Pengcheng Liu (ORCID: https://orcid.org/0000-0002-1860-5118)
- Jiacheng Xu (ORCID: https://orcid.org/0000-0002-9292-6999)
- Zhiqian Wang (ORCID: https://orcid.org/0000-0001-9831-649X)
- Yanhong Liu (ORCID: https://orcid.org/0000-0001-7727-4796)
- Jinyong Wang (ORCID: https://orcid.org/0000-0002-7218-0659)
- Fangxiao Hu (ORCID: https://orcid.org/0009-0000-9376-6870)
- Xiaofan Zhu (ORCID: https://orcid.org/0000-0003-3760-8143)
- Yanping Zhu (ORCID: https://orcid.org/0000-0003-4524-0350)
- Tongjie Wang (ORCID: https://orcid.org/0000-0003-1207-8377)
- Jiaxin Wu
- Hanmeng Qi
- Yiyuan Shen (ORCID: https://orcid.org/0009-0000-5954-270X)
- Wenbin Qian (ORCID: https://orcid.org/0000-0002-6138-5616)
- Yaoqin Zhao
- Aibin Liang
Institutions
- Tongji University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
- Tongji Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Institute of Zoology (CN)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s13045-025-01712-3
- Citations
- 7
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 7.32
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China