Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease
Copathologies play an important role in symptom severity in individuals who harbor less tau-tangle pathology than expected for their clinical impairment. These results highlight the importance of measuring non-AD biomarkers in patients with AD with worse cognitive impairment than expected based on their biological stage, which could impact the clinical diagnosis and prognosis.
Authors
- Donna Masterman
- Evan Fletcher (ORCID: https://orcid.org/0000-0002-9761-3131)
- Emily A. Largent (ORCID: https://orcid.org/0000-0002-7536-5077)
- Winnie Kwang
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Payam Mahboubi
- Magdalena Korecka (ORCID: https://orcid.org/0000-0003-3129-8295)
- Alexander Knaack (ORCID: https://orcid.org/0000-0002-5231-3637)
- Robert I. Reid (ORCID: https://orcid.org/0000-0003-2391-8650)
- Juliet Fockler
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-8644-7724)
- Richard J. Perrin (ORCID: https://orcid.org/0000-0002-3443-7716)
- Jason Karlawish (ORCID: https://orcid.org/0000-0002-6880-2865)
- Alexa Pichet Binette (ORCID: https://orcid.org/0000-0001-5218-3337)
- Nina Silverberg
- Arthur W. Toga (ORCID: https://orcid.org/0000-0001-7902-3755)
- Sophia I. Thomopoulos (ORCID: https://orcid.org/0000-0002-0046-4070)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Neda Jahanshad (ORCID: https://orcid.org/0000-0003-4401-8950)
- Karen Crawford (ORCID: https://orcid.org/0000-0002-3294-0828)
- Lisa Thomas (ORCID: https://orcid.org/0000-0001-5860-2141)
- Piero Parchi (ORCID: https://orcid.org/0000-0002-9444-9524)
- Sebastian Palmqvist (ORCID: https://orcid.org/0000-0002-9267-1930)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Miriam T. Ashford (ORCID: https://orcid.org/0000-0003-4045-6435)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Andrea Fidell
- John Q. Trojanowki
- Mónica Rivera Mindt (ORCID: https://orcid.org/0000-0001-6350-321X)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Erin Franklin (ORCID: https://orcid.org/0000-0002-6614-4109)
- Elizabeth Shaffer
- Marie Bernard (ORCID: https://orcid.org/0000-0003-3807-8009)
- Pontus Tideman (ORCID: https://orcid.org/0000-0002-9620-7115)
- Joe Strong
- Cecily Jenkins
- Arvin Forghanian-Arani
- Michael Donohue (ORCID: https://orcid.org/0000-0001-6026-2238)
- Tom Montine
- Yuliana Cabrera
- Kristin Harkins (ORCID: https://orcid.org/0000-0001-5360-1043)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Paul S. S Aisen (ORCID: https://orcid.org/0000-0002-2896-5838)
- Stephanie Rossi Chen
- John Hsiao (ORCID: https://orcid.org/0000-0003-3471-7539)
- Caitie Hedberg
- Danielle Harvey
- Charles DeCarli
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Jeremy Pizzola
- Ruben Smith (ORCID: https://orcid.org/0000-0001-7147-0112)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Jonathan Jackson (ORCID: https://orcid.org/0000-0002-3175-4898)
- Sheila Ogwang
- Niklas Mattsson (ORCID: https://orcid.org/0000-0002-8885-7724)
- Sarah Walter (ORCID: https://orcid.org/0009-0003-3222-3102)
- Maria Carrillo
- Diana Truran Sacrey
- Joel P. Felmlee (ORCID: https://orcid.org/0000-0002-6058-5835)
- Zoë Potter
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Kaci Lacy
- Magdalena Brylska
- Tatiana Foroud
- Mark Choe
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Taeho Jo (ORCID: https://orcid.org/0000-0001-7448-9433)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Haley Bernhardt
- Caileigh Zimmerman
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Taylor Clanton
- Bret Borowski
- Derek Flenniken
- Zaven Kachaturian
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
- Laurel Beckett (ORCID: https://orcid.org/0000-0002-2418-9843)
- Joshua D. Grill (ORCID: https://orcid.org/0000-0002-4215-7589)
- Paul A. Yushkevich (ORCID: https://orcid.org/0000-0001-8543-4016)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Gemma Salvadó (ORCID: https://orcid.org/0000-0002-5210-9230)
- Chengshi Jin (ORCID: https://orcid.org/0000-0002-6431-790X)
- Olusegun Adegoke
- Isabelle Glans
- Colin Groot (ORCID: https://orcid.org/0000-0002-5802-6946)
- Edward B. Lee (ORCID: https://orcid.org/0000-0002-4589-1180)
- John C. Morris (ORCID: https://orcid.org/0000-0001-9820-5618)
- Virginia M.‐Y. Lee (ORCID: https://orcid.org/0000-0003-3536-6902)
- Rema Raman (ORCID: https://orcid.org/0000-0002-4096-6390)
- Brian J. Lopresti
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Neil Buckholtz
- Nigel J. Cairns (ORCID: https://orcid.org/0000-0001-9858-3344)
- Ian B. Malone (ORCID: https://orcid.org/0000-0001-7512-7856)
- Danielle van Westen (ORCID: https://orcid.org/0000-0001-8649-9874)
- Héctor Alfredo Baptista González (ORCID: https://orcid.org/0000-0003-0340-0942)
- Eliezer Masliah (ORCID: https://orcid.org/0000-0002-2117-5569)
- Talia M. Nir (ORCID: https://orcid.org/0000-0002-7106-7443)
- Cat Conti
- Richard Frank (ORCID: https://orcid.org/0000-0001-5927-1217)
- Vanessa Guzmán (ORCID: https://orcid.org/0009-0003-2930-4155)
- Kaj Blennow
- Melanie J. Miller (ORCID: https://orcid.org/0000-0002-7189-1109)
- Lindsey Hergesheimer
- Rachel L. Nosheny (ORCID: https://orcid.org/0000-0003-4995-8319)
- Sandra Talavera (ORCID: https://orcid.org/0000-0001-9272-0547)
- Erin Drake
- Robert A. Koeppe (ORCID: https://orcid.org/0000-0002-9514-5311)
- Adrienne Kormos
- Paul Thompson (ORCID: https://orcid.org/0009-0009-5319-739X)
- Susan Landau (ORCID: https://orcid.org/0000-0003-4826-6134)
- Peter J. Snyder (ORCID: https://orcid.org/0000-0003-0555-4654)
- Kwangsik Nho
- Zaven S. Khachaturian
- Calvin Reyes
- Hannah Craft
- Yang Wan (ORCID: https://orcid.org/0009-0003-8542-0900)
- Li Shen (ORCID: https://orcid.org/0000-0001-8295-7065)
- Leslie M. Shaw (ORCID: https://orcid.org/0000-0002-7650-1210)
- Robert C. Green (ORCID: https://orcid.org/0000-0001-8472-0424)
- Claire M. Erickson (ORCID: https://orcid.org/0000-0003-0392-0198)
- Stephanie Smith (ORCID: https://orcid.org/0000-0002-6892-4379)
- Justin Robison (ORCID: https://orcid.org/0009-0008-6428-693X)
- Naomi Saito (ORCID: https://orcid.org/0009-0006-7858-9267)
- Michael Walter Weiner (ORCID: https://orcid.org/0000-0002-0144-1954)
- Denise A. Reyes
- Laurie Ryan
- Kelley Faber (ORCID: https://orcid.org/0000-0003-3224-2736)
- Virginia Boatwright
- Joseph Di Benedetto
- Hannatu Amaza
- Omobolanle Ayo
- Trinity Weisensel
- John Moore-Weiss
- Leonard Matoush
- Shaniya Parkins
- Matt Glittenberg
- Kaori Kubo Germano
- William Z. Potter
- William Jagust
- Carole Ho (ORCID: https://orcid.org/0000-0003-4250-092X)
- Shorena Janelidze
- Adam Diaz
- Scott Neu
- Susan Molchan
- Fabiola Magana
- Leon J. Thal
- Ronald Petersen (ORCID: https://orcid.org/0009-0006-8296-6416)
- Rima Kaddurah-Daouk
- Michael Rafii
- Isabella Hoang
- Adeyinka Ajayi
- Mai Seng Thao
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Jennifer Salazar
- Lisa Taylor‐Reinwald
- Chad Ward
- Jeff Gunter
- Caitlin Webb
- Kedir Adem Hussen
- Kejal Kantarci
- Gustavo Jiménez
Institutions
- University of Science and Technology of China (CN)
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Pitié-Salpêtrière Hospital (FR)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- UK Dementia Research Institute (GB)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Skåne University Hospital (SE)
- Institut du Cerveau (FR)
- University College London (GB)
- Université de Montréal (CA)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- University of Bologna (IT)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1001/jamaneurol.2025.1100
- Citations
- 27
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 39.72
Funders
- Alzheimer's Association
- University of Wisconsin-Madison
- GHR Foundation
- Lunds Universitet
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Göteborgs Universitet
- Università di Bologna
- University of Science and Technology of China
- Skånes universitetssjukhus
- UK Dementia Research Institute
- Sorbonne Université
- School of Medicine and Public Health, University of Wisconsin-Madison
- Sahlgrenska Akademin
- School of Life Sciences and Biotechnology Division of Life Sciences, Korea University