Tiotropium Initiation and Dementia Risk in Chronic Obstructive Pulmonary Disease
In this cohort study, among older adults with COPD, the small absolute rate increase in incident dementia associated with tiotropium monotherapy vs LABA-ICS was of questionable clinical importance, particularly when weighed against the established clinical benefits of tiotropium.
Authors
- Tetyana Kendzerska (ORCID: https://orcid.org/0000-0002-5301-1796)
- Christa Wang
- Che-Yuan Wu
- Jodi D. Edwards (ORCID: https://orcid.org/0000-0002-9275-4787)
- Refik Saskin (ORCID: https://orcid.org/0000-0002-8641-7725)
- Walter Swardfager (ORCID: https://orcid.org/0000-0002-0030-8908)
- Lisa Y. Xiong (ORCID: https://orcid.org/0000-0002-6342-9336)
- Peter P. Liu (ORCID: https://orcid.org/0000-0002-3017-1199)
Institutions
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Ottawa (CA)
- University of Toronto (CA)
- Toronto Rehabilitation Institute (CA)
- Ottawa Hospital (CA)
- Institute for Clinical Evaluative Sciences (CA)
- Ottawa Hospital Research Institute (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- JAMA Internal Medicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1001/jamainternmed.2025.1251
- Citations
- 3
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56