Copper-Catalyzed Chemoselective Hydrogenation of Unsaturated Bonds with Formic Acid/Formate as Hydrogen Donor
A novel and sustainable strategy, using earth abundant Cu<sub>2</sub>O as catalyst and biorenewable HCOOH/HCOOK as hydrogen donor for the efficient hydrogenation of multiple unsaturated compounds, including internal and terminal alkynes, ketones, aldehydes, and imines, has been developed to access high-value chemicals with high chemoselectivity. This protocol features operation simplicity, wide substrate applicability, and only CO<sub>2</sub> as a byproduct. Additionally, gram-scale experiments and the modification of biologically active molecules all exemplified the synthetic versatility of this protocol.
Authors
- Liang‐Nian He (ORCID: https://orcid.org/0000-0002-6067-5937)
- Jiaoyu Peng (ORCID: https://orcid.org/0000-0002-1220-2203)
- Chao‐Jun Li (ORCID: https://orcid.org/0000-0002-3859-8824)
- Shumei Xia (ORCID: https://orcid.org/0000-0003-0273-3630)
- Taoshan Xu (ORCID: https://orcid.org/0000-0002-8922-7310)
- Xin Liu (ORCID: https://orcid.org/0000-0002-4422-4108)
- Lijuan Li
- Dawei Cao (ORCID: https://orcid.org/0000-0003-0516-9844)
- Shaolei Xie
Institutions
- Chinese Academy of Sciences (CN)
- Nankai University (CN)
- Centre in Green Chemistry and Catalysis (CA)
- Institute of Organic Chemistry (HU)
- McGill University (CA)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1021/acs.orglett.5c01372
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canada Foundation for Innovation
- Canada Research Chairs
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Fonds Québécois de la Recherche sur la Nature et les Technologies
- Qinghai Provincial Department of Science and Technology
- Natural Sciences and Engineering Research Council of Canada
- Chinese Academy of Sciences Key Project