Gastroprotective Effect Of Bezafibrate And Ginkgo Biloba In Ethanol-Induced Gastric Ulcer In Rats

Background: Gastric ulcer disease is a common and recurring gastrointestinal condition affecting millions annually. Several medications are available for the treatment of gastric ulcers; however, their adverse reactions attenuate their usefulness. Objective: the current study was designed to evaluate the possible synergistic gastroprotective effects of combining bezafibrate with ginkgo biloba (GKB) in ethanol-induced gastric ulcers. Methods: Thirty male Wister albino rats were randomly distributed into six groups each of 6 rats as follows: Negative control, positive control, esomeprazole group, bezafibrate group, and bezafibrate + GKB. All the medications were administered orally and a single dose of ethanol (1 ml) was administered on day 14 for groups III, IV, V and VI. After scarification, blood samples were gathered and the stomachs were excised for gross evaluation. Results: The combination group showed decreased gastric free and total acidity, LDH and raised gastric pH and GSH levels. Gross evaluation of stomach images showed remarkable protection in the combination group. Conclusion: The combination of bezafibrate with ginkgo biloba extract in the current study exerted more gastroprotective effect than each alone suggesting they could work synergistically to guard the gastric mucosa from ethanol-induced destruction via decreasing gastric acidity, and inflammatory mediators and boost the antioxidant system.