Timing of Antenatal Corticosteroid Administration and Neonatal Outcomes

In this cohort of neonates born from 23 weeks 0 days' gestation to 31 weeks 6 days' gestation, ACS administration was associated with a reduction in neonatal mortality as early as 2 hours after the administration of the first dose. The interval associated with the greatest reduction in neonatal mortality was between 12 hours and 14 days before birth, which was wider than the currently accepted optimal interval of 1 to 7 days. These findings may have important clinical implications for the management of pregnancies at risk of preterm birth, particularly regarding the administration of ACS even in cases in which preterm birth is imminent, and the timing of repeat courses of ACS.

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Publication Details

Journal
JAMA Network Open
Published
2025-05-19
DOI
https://doi.org/10.1001/jamanetworkopen.2025.11315
Citations
7
Primary Topic
Neonatal Respiratory Health Research
Type
article
Field-Weighted Citation Impact
10.63
Controls
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article

Timing of Antenatal Corticosteroid Administration and Neonatal Outcomes

Chelsea Ruth, Jennifer Toye, Keith J. Barrington, Andrzej Kajetanowicz et al.
7 citations
JAMA Network Open
Neonatal Respiratory Health Research
10.63
article

Timing of Antenatal Corticosteroid Administration and Neonatal Outcomes

Chelsea Ruth, Jennifer Toye, Keith J. Barrington, Andrzej Kajetanowicz, Bruno Piedbœuf, Christy Pylypjuk, Ayman Abou Mehrem, Miroslav Stavel, Wissam Alburaki, Faiza Khurshid, Lannae Strueby, Ann Yi, Hala Makary, Édith Massé, Victoria Bizgu, Gabriela de Carvalho Nunes, Guillaume Éthier, Marie St‐Hilaire, Valérie Bertelle, Jo-Anna Hudson, Anie Lapointe, Brigitte Lemyre, Marco Zeid, Joseph Ting, Andrei Harabor, Sajit Augustine, Thevanisha Pillay, Rebecca Sherlock, Amit Mukerji, Aziz Ahmad, Deepak Louis, Christine Drolet, Prakesh S. Shah, Kellie E. Murphy, Kyong‐Soon Lee, Carlos Fajardo, Jonathan Wong, Paloma Costa, Nir Melamed, Kevin Coughlin, Eugene W. Yoon, Mary Seshia, Marc Beltempo, Jehier Afifi, Nina Nouraeyen
article en
7 citations

Abstract

In this cohort of neonates born from 23 weeks 0 days' gestation to 31 weeks 6 days' gestation, ACS administration was associated with a reduction in neonatal mortality as early as 2 hours after the administration of the first dose. The interval associated with the greatest reduction in neonatal mortality was between 12 hours and 14 days before birth, which was wider than the currently accepted optimal interval of 1 to 7 days. These findings may have important clinical implications for the management of pregnancies at risk of preterm birth, particularly regarding the administration of ACS even in cases in which preterm birth is imminent, and the timing of repeat courses of ACS.

JAMA Network OpenVol. 8(5)
Mount Sinai Hospital (CA), Sunnybrook Health Science Centre (CA), University of British Columbia (CA), University of Toronto (CA), Surrey Memorial Hospital (CA), Centre Hospitalier Universitaire Sainte-Justine (CA), Health Sciences Centre (CA), University of Manitoba (CA)
Good health and well-being
Openalex Percentile: Top 2%
Neonatal Respiratory Health Research
10.63
DOIOpen Access PDFOpenAlex
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