Differential significance of Seminal Cell-Free DNA Levels, Oxidative Stress, and Sperm Characteristic between Infertile Men with Nonobstructive and obstructive Azoospermia

This study highlights the direct link between elevated cfDNA levels, oxidative stress, and impaired sperm parameters in men with azoospermia and oligospermia. Current data underscore the potential competence of cfDNA and oxidative stress as diagnostic tools to classify the severity of male infertility and abnormalities related to semen parameters. Our findings emphasize the importance of antioxidant therapy as an efficient strategy to reduce oxidative damage, enhance sperm quality, and improve reproductive outcomes for male partners of couples with infertility.