Nrf2 Deficiency Brings About Increased Sensitive to IR and 7,12-dimethylbenz(a)anthracene and Leukemia Predisposition
We demonstrate that the genetic deficiency of Nrf2 in mice leads to reduced antioxidant capacity and suppression of hematopoietic and immune system function, resulting in increased sensitivity to IR or DMBA.
Authors
- Shasha Nie
- Mingxin Dong (ORCID: https://orcid.org/0000-0001-8623-0146)
- Xinyu Zhang (ORCID: https://orcid.org/0009-0008-0290-7374)
- Xiaohui Sun (ORCID: https://orcid.org/0009-0006-2964-4768)
- Ping Yang (ORCID: https://orcid.org/0000-0002-1641-9389)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Tianjin Institute of Pharmaceutical Research (China) (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Dose-Response
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1177/15593258251341593
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province