Mesenchymal stem cells protect the integrity of the alveolar epithelial barrier through extracellular vesicles by inhibiting MAPK-mediated necroptosis
Our results suggest that human menstrual blood-derived endometrial stem cells mitigate lung injury and improve alveolar barrier properties by inhibiting MAPK-mediated necroptosis through extracellular vesicles, supporting the application of MenSCs or MenSC-derived extracellular vesicles to treat ALI or ARDS.
Authors
- Tao Ruan
- Chengxu Xue
- Juntang Lin (ORCID: https://orcid.org/0000-0001-9300-1771)
- Fengyuan Wang (ORCID: https://orcid.org/0000-0003-2373-0316)
- Jiaming Han
Institutions
- Henan Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s13287-025-04388-1
- Citations
- 9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 7.25