Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation
Taken together, these data demonstrate that spermidine is the key immunomodulatory component downstream of arginine metabolism and that it mediates this effect by stimulating hypusination-dependent protection of OXPHOS in DC, which in turn results in a reduced ability of DC to activate and interact with T cells. This pathway may be utilized by the immune system to regulate excessive immune responses but could also be exploited by pathogens as a method of immune evasion.
Authors
- Larissa Camargo da Rosa (ORCID: https://orcid.org/0000-0002-4849-8835)
- Georgia Perona‐Wright (ORCID: https://orcid.org/0000-0003-2761-4275)
- Utku Gunes
- Hannah E. Scales (ORCID: https://orcid.org/0000-0002-4247-2802)
- George Finney (ORCID: https://orcid.org/0000-0002-4230-4235)
- James M. Brewer (ORCID: https://orcid.org/0000-0001-7933-0915)
- Gavin R. Meehan (ORCID: https://orcid.org/0000-0001-9855-6565)
- Ross Deehan
- Sofia Sintoris
- Aegli Athanasiadou
- J. E. Jones
Institutions
- Institute of Infection and Immunity (CA)
- University of Glasgow (GB)
Publication Details
- Journal
- Discovery Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/discim/kyaf009
- Citations
- 1
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Wellcome Trust