Dose-dependent association between proton pump inhibitor use and the risk of migraine: a nationwide matched case–control study
This large-scale Asian population study revealed a significant dose-dependent association between PPI exposure and increased migraine risk, emphasizing the need for cautious prescribing and monitoring of migraine symptoms in long-term PPI users, particularly in Asian populations.
Authors
- Yue Ruan (ORCID: https://orcid.org/0000-0003-3498-2543)
- Fu‐Chi Yang (ORCID: https://orcid.org/0000-0001-6831-3634)
- Chih‐Sung Liang (ORCID: https://orcid.org/0000-0003-1138-5586)
- Chia‐Kuang Tsai (ORCID: https://orcid.org/0000-0001-7693-1408)
- Shih‐Jen Tsai (ORCID: https://orcid.org/0000-0002-9987-022X)
- Chia-Fen Tsai
- Ya‐Mei Bai (ORCID: https://orcid.org/0000-0003-3779-9074)
- Mu-Hong Chen
- Tzeng-Ji Chen
- Tung‐Ping Su
Institutions
- Tri-Service General Hospital (TW)
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- Tri-Service General Hospital Beitou Branch (TW)
- Cheng Hsin General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Postgraduate Medical Journal
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1093/postmj/qgaf077
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology
- Yen Tjing Ling Medical Foundation
- Tri-Service General Hospital
- Taipei Veterans General Hospital
- Medical Affairs Bureau