GIANT: a prospective, multicenter, real-world study on the effectiveness, safety, and tolerability of atogepant in migraine patients with multiple therapeutic failures
The GIANT study provides real-world evidence of atogepant's effectiveness, safety, and tolerability in patients with HFEM and CM with multiple therapeutic failures and comorbidities. It extends RCT data by showing rapid onset of action, meaningful reductions in pain intensity and interictal disability, high patient satisfaction, and effectiveness even in patients with anti-CGRP mAb failures.
Authors
- Cinzia Aurilia (ORCID: https://orcid.org/0000-0002-2658-2243)
- Maria Albanese (ORCID: https://orcid.org/0000-0002-5113-2017)
- Piero Barbanti (ORCID: https://orcid.org/0000-0002-5670-3755)
- Rosario Vecchio
- Francesca Pistoia (ORCID: https://orcid.org/0000-0003-0790-4240)
- Massimo Autunno (ORCID: https://orcid.org/0000-0002-7526-2799)
- Francesco Bono (ORCID: https://orcid.org/0000-0002-4650-6635)
- Stefano Bonassi (ORCID: https://orcid.org/0000-0003-3833-6717)
- Maurizio Zucco
- Antonio Salerno
- Paola Torelli (ORCID: https://orcid.org/0000-0002-4072-2353)
- Carlo Tomino (ORCID: https://orcid.org/0000-0003-1823-2195)
- P. Bruno
- Fabio Frediani
- Cecilia Camarda
- Gabriella Egeo (ORCID: https://orcid.org/0000-0003-3068-4522)
- Silvia Strumia
- Steno Rinalduzzi
- Alberto Doretti (ORCID: https://orcid.org/0000-0002-1015-7365)
- L. Borrello (ORCID: https://orcid.org/0000-0001-6801-7966)
- Giulia Fiorentini
- Alice Mannocci (ORCID: https://orcid.org/0000-0002-8527-6940)
- Laura Di Clemente (ORCID: https://orcid.org/0000-0002-2426-1163)
- Stefano Messina (ORCID: https://orcid.org/0000-0002-5150-7050)
- Andrea Galli
- Paola Scatena
- Angelo Ranieri
- Valeria Drago
Institutions
- University of Messina (IT)
- University of Rome Tor Vergata (IT)
- University of Parma (IT)
- Vita-Salute San Raffaele University (IT)
- University of L'Aquila (IT)
- Azienda Ospedaliera San Giovanni Addolorata (IT)
- San Raffaele University of Rome (IT)
- Accademia di Belle Arti di Frosinone (IT)
- Ospedale Antonio Cardarelli (IT)
- Ellis Hospital (US)
- Ospedale San Carlo (IT)
- Fatebenefratelli Hospital (IT)
- Ospedale G.B. Morgagni - L.Pierantoni (IT)
- IRCCS Ospedale San Raffaele (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Carlo Forlanini Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Servy Institute for Reproductive Endocrinology (US)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Palermo (IT)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s10194-025-02068-2
- Citations
- 12
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 17.65
Funders
- Ministero della Salute