<scp>TNFα</scp> Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model
TNFα receptor-specific signaling is important in rat IVDD in vivo and in vitro. TNFR1 inhibition was more effective with small molecules than using blocking antibodies. Low levels of TNFR2 in rat AF and NP cells and lack of efficacy of TNFR2-activator Atsttrin suggest native AF and NP cells have little capacity for TNFR2-dependent IVD repair.
Authors
- James C. Iatridis (ORCID: https://orcid.org/0000-0002-2186-0590)
- Damien M. Laudier (ORCID: https://orcid.org/0000-0003-4674-7460)
- James Meyers (ORCID: https://orcid.org/0000-0002-5948-6581)
- Jennifer Gansau (ORCID: https://orcid.org/0000-0002-1951-2933)
- Timothy Jacobsen (ORCID: https://orcid.org/0000-0001-8944-8095)
- S. Olga Yiantsos
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/jsp2.70070
- Citations
- 2
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases