Targeting the hydrophobic pockets of FAK/PYK2 FAT domain: a highly effective inhibitory strategy suppressing tumor growth and eliminating metastasis
Targeting the FAT domain hydrophobic patches of FAK/PYK2 is a highly effective inhibitory strategy that can overcome the limitations of existing ATP competitive inhibitors and lead to the development of novel inhibitors with strong antitumor and antimetastatic activity.
Authors
- Maria Christoforou (ORCID: https://orcid.org/0009-0001-8821-3005)
- Anna Charalambous
- Paris A. Skourides (ORCID: https://orcid.org/0000-0003-3502-5729)
- Dimitrios Sfakianakis
Institutions
- University of Cyprus (CY)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s12964-025-02203-1
- Citations
- 2
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- University of Cyprus
- Research and Innovation Foundation