Comparison of Efficacy of Misoprostol vs Foley and Misoprostol Combination in Second Trimester Medical Termination of Pregnancy

Introduction: Both surgical and medical methods are used for medical termination of pregnancy (MTP).Aims and objectives: To compare the efficacy of misoprostol vs Foley and misoprostol combination in second trimester MTP.Materials and methods: It was a comparative cross-sectional, observational study, consisting of two groups with each having 48 subjects.Procedure: Group A (misoprostol)-The subjects in this group received tablet misoprostol 600 gm stat kept vaginally.Later, every 4th hourly, 400 gm tablet misoprostol was kept vaginally, with a maximum of five doses.Group B (Foley catheter and misoprostol)-In this group, subjects received intracervical Foley catheter under aseptic precautions.The Foley catheter inflated around 30-50 mL saline.It was tied to the right thigh.Then, simultaneously tablet misoprostol 600 gm stat was kept vaginally.Later, every 4th hourly, 400 gm tablet misoprostol was kept vaginally, with a maximum of five doses.Results: Foley with misoprostol has 97.92% success and only misoprostol has 81.25%, with statistical significance (p = 0.007).The mean inductionto-abortion interval in misoprostol alone group was 18.15 hours and with Foley catheter combination it was only 12.1 hours. Conclusion:The MTP by combination of Foley catheter with misoprostol has lesser induction-to-abortion interval and higher success rate than using misoprostol alone.