<scp>Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA</scp> Class I Down‐Regulated Senescent Epidermal Basal Cells
Senescent cells create a microenvironment that directs cytotoxic T cell-mediated responses against normal epidermis in patients with CLE, contributing to disease pathology. Targeting senescent cells and their signaling pathways may offer novel therapeutic strategies for patients with skin lesions from CLE and SLE.
Authors
- Koji Taniguchi (ORCID: https://orcid.org/0000-0002-8091-6005)
- Takako Chikenji (ORCID: https://orcid.org/0000-0003-2832-3656)
- Souichiro Nakano
- Sena Yamamoto (ORCID: https://orcid.org/0000-0002-7961-697X)
- Maki Miyajima (ORCID: https://orcid.org/0000-0002-0861-781X)
- Norihiro Miura
- Shogo Ijima
- Kentaro Nagaoka (ORCID: https://orcid.org/0000-0003-1038-1380)
- Arisa Kita (ORCID: https://orcid.org/0000-0001-5130-6075)
- Ayaka Nagao (ORCID: https://orcid.org/0000-0002-6591-2743)
- Atsushi Niida (ORCID: https://orcid.org/0000-0002-6851-8004)
- Yuki Saito (ORCID: https://orcid.org/0000-0002-7949-1628)
- Tsukasa Sato
- Dain Kasseki
Institutions
- Sapporo Medical University (JP)
- Health Sciences University of Hokkaido (JP)
- Sapporo University (JP)
- Hokkaido University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1002/art.43244
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59