The comprehensive transcriptomic atlas of porcine immune tissues and the peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genes
Our study elucidated the fundamental transcriptional program in porcine immune tissues and the immunodynamics underlying development of PBMCs, identifying many core immune genes, including IFI44, which plays a critical negative regulator role in the antiviral response, providing valuable insights for breeding programs aimed at enhancing pig disease resistance.
Authors
- Huatao Liu (ORCID: https://orcid.org/0000-0002-2381-2584)
- Siyuan Mi (ORCID: https://orcid.org/0000-0003-4950-689X)
- Chuduan Wang (ORCID: https://orcid.org/0009-0009-7826-5467)
- Quanzhen Chen (ORCID: https://orcid.org/0000-0002-7481-9997)
- Jinyan Yang
- Yongjie Tang (ORCID: https://orcid.org/0000-0002-3298-9023)
- Ying Yu (ORCID: https://orcid.org/0000-0003-4772-413X)
- Qingyao Zhao (ORCID: https://orcid.org/0000-0002-1037-3631)
- Xini Wang
- Kai Xing (ORCID: https://orcid.org/0000-0002-2556-6946)
- Siqian Chen (ORCID: https://orcid.org/0009-0004-4737-7443)
- Guohong Liu (ORCID: https://orcid.org/0000-0001-7817-3890)
- Fuping Ma
- Lulu Wang (ORCID: https://orcid.org/0009-0004-5328-8420)
- Jiahao Wang (ORCID: https://orcid.org/0009-0008-6878-3597)
Institutions
- Ministry of Agriculture (ID)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s40104-025-01184-y
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China