Possible mechanisms of homocysteine in the pathogenesis of depressive disorder

Depressive disorder is one of the mental illnesses with the highest global disability rates. Homocysteine (Hcy), a non-essential sulfur-containing amino acid, serves as a significant risk factor in the development and progression of various diseases. Current research has revealed a close association between Hcy and depressive disorder. This review focuses on elucidating the mechanisms of Hcy in the pathogenesis of depressive disorder and explores its potential as both a biomarker and a therapeutic target.