Involvement and Role of Macrophage Polarization in Ulcerative Colitis

作为先天免疫细胞，巨噬细胞广泛存在于所有组织中，并在发育、防御和抗炎等方面发挥着重要作用。溃疡性结肠炎的发生、发展受到巨噬细胞的显著影响。M1型巨噬细胞主要产生促炎因子，而M2型巨噬细胞主要参与抗炎过程和组织修复。肠道M1/M2巨噬细胞的极化失衡与溃疡性结肠炎密切相关。本文就巨噬细胞的起源、分类、功能及其在溃疡性结肠炎中的参与和作用进行综述，以期为基于巨噬细胞极化治疗溃疡性结肠炎的药物开发和应用提供参考。As innate immune cells, macrophages widely exist in all tissues and play an important role in development, defense and anti-inflammation. The occurrence and development of ulcerative colitis are significantly affected by macrophages. M1 macrophages mainly produce pro-inflammatory factors, while M2 macrophages are mainly involved in anti-inflammatory processes and tissue repair. The polarization imbalance of intestinal M1/M2 macrophages is closely related to ulcerative colitis. This article reviews the origin, classification, function of macrophages and their involvement and role in ulcerative colitis, hoping to provide references for the development and application of drugs based on macrophage polarization in the treatment of ulcerative colitis.