An Updated Review on Floating Microspheres for Gastro-Retentive Drug Delivery System

The purpose of gastro-retentive drug delivery devices (GRDDs) is to extend a drug's half-life in the stomach. This could be helpful for drugs that need to be taken on a sustained-release schedule or that are hydrolyzed by stomach acid. The goal of the floating microsphere is to extend the duration of gastric retention. Floating drug delivery methods float on gastric juice for extended periods of time without affecting the rate of stomach emptying and enhancing biodegradability because they have a lower bulk thickness than gastric juice. With their low dose risk, reproducible short stomach retention period, and mixing versatility to generate multiple release patterns, gastrointestinal-retentive microspheres especially well-suited for the continuous or late release of oral formulations. The purpose of this study is to discuss the floating device literature, methods, low density polymers utilized to swim over stomach fluid, procedures, Evaluation and use of floating microspheres, and the identification of appropriate or inappropriate drug candidates for GRDDS.