Incidence rate and malignancy risk in new nodules in a lung cancer screening programme
Question What is the incidence and malignancy risk of new nodules appearing at annual and nodule follow-up interval CTs in lung cancer screening? Findings New nodules were seen in 11.1% and 8.4% of participants at annual low-dose CT and 3-month interval CT, respectively. Malignancy risk at annual CT increased with nodule size. Clinical relevance In a lung cancer screening programme, new nodules at annual and nodule follow-up CTs occur in around 1 in 10 participants. Lower size thresholds for further surveillance or definitive investigation should be considered compared to nodules at baseline CT.
Authors
- Amyn Bhamani (ORCID: https://orcid.org/0000-0002-8575-6119)
- Allan Hackshaw (ORCID: https://orcid.org/0000-0002-5570-5070)
- Priyam Verghese (ORCID: https://orcid.org/0000-0002-1319-3986)
- Carolyn Horst (ORCID: https://orcid.org/0000-0003-2427-6610)
- Sophie Tisi
- Jennifer Dickson (ORCID: https://orcid.org/0000-0002-9333-8320)
- Chuen Ryan Khaw (ORCID: https://orcid.org/0009-0009-0462-7883)
- Kylie Gyertson
- Laura Farrelly (ORCID: https://orcid.org/0000-0002-0039-6709)
- Sam M. Janes (ORCID: https://orcid.org/0000-0002-6634-5939)
- Andrew Creamer (ORCID: https://orcid.org/0000-0002-9314-1210)
- Helen Hall (ORCID: https://orcid.org/0000-0001-7305-8367)
- Arjun Nair (ORCID: https://orcid.org/0000-0001-9270-3771)
- Ruth Prendecki
- Anne-Marie Hacker
- John McCabe
- Anand Devaraj
Institutions
- Barking, Havering And Redbridge University Hospitals NHS Trust (GB)
- North Bristol NHS Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Queen Mary University of London (GB)
- Royal Free London NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- Anthony Nolan (GB)
- Princess Alexandra Hospital NHS Trust (GB)
- Cancer Research UK (GB)
- Papworth Hospital NHS Foundation Trust (GB)
- King's College Hospital NHS Foundation Trust (GB)
- Homerton University Hospital NHS Foundation Trust (GB)
- London Borough of Tower Hamlets (GB)
- Imagerie Médicale et Radiothérapie Drôme Ardèche (FR)
- Whittington Health NHS Trust (GB)
- The London College (GB)
- North Middlesex University Hospital NHS Trust (GB)
- University Hospitals Sussex NHS Foundation Trust (GB)
- Surrey and Sussex Healthcare NHS Trust (GB)
- Royal United Hospital Bath NHS Trust (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- European Radiology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1007/s00330-025-11576-3
- Citations
- 1
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Roy Castle Lung Cancer Foundation
- Wellcome Trust
- UCL Hospitals Charitable Foundation
- Cancer Research UK
- Rosetrees Trust
- University College London Hospitals NHS Foundation Trust