Management of relapsed or refractory large B‐cell lymphoma: A British Society for Haematology Guideline
Time to progression is the strongest predictor of outcome in relapsed diffuse large B-cell lymphoma. Second-line treatment with chimeric antigen receptor (CAR) T-cell therapy is recommended for patients with progression within 12 months of first-line chemoimmunotherapy. In patients with late relapse, platinum-based chemotherapy followed by high-dose chemotherapy with autologous stem cell rescue is recommended. In second relapse, CAR T-cell or CD3xCD20 bispecific antibody therapy is recommended in eligible patients. Other treatment options are available for less fit patients. Specific recommendations are made on diagnostic immunohistochemistry, bendamustine use and bridging to CAR T-cell therapy.
Authors
- Nagesh Kalakonda (ORCID: https://orcid.org/0000-0002-5300-1360)
- Pam McKay (ORCID: https://orcid.org/0000-0002-3959-9730)
- Kate Cwynarski (ORCID: https://orcid.org/0000-0001-9936-3431)
- Andrea Kühnl (ORCID: https://orcid.org/0000-0002-4952-2550)
- Sally F. Barrington (ORCID: https://orcid.org/0000-0002-2516-5288)
- Toby A. Eyre (ORCID: https://orcid.org/0000-0002-6631-9749)
- Andrew John Davies (ORCID: https://orcid.org/0000-0002-7517-6938)
- Tim Illidge (ORCID: https://orcid.org/0000-0003-3191-7324)
- Christopher P. Fox (ORCID: https://orcid.org/0000-0002-6322-9254)
- Bernard Maybury (ORCID: https://orcid.org/0000-0001-7064-8900)
- Cathy Burton
- Sridhar Chaganti
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- University of Nottingham (GB)
- University of Liverpool (GB)
- King's College London (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Beatson West of Scotland Cancer Centre (GB)
- University of Manchester (GB)
- University of Oxford (GB)
- NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
- King's College Hospital (GB)
- NIHR Manchester Biomedical Research Centre (GB)
- University of Southampton (GB)
- University College London (GB)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1111/bjh.20129
- Citations
- 4
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.89