The gene regulatory mechanisms shaping the heterogeneity of venom production in the Cape coral snake

Our results provide new insight into the variability of toxin regulation across snakes, reveal the molecular mechanisms underlying the heterogeneous toxin production in snake venom glands, and provide an example of how constraints can result in non-adaptive character states that appear to be adaptive, which may nevertheless facilitate evolutionary innovation and novelty.

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Publication Details

Journal
Genome biology
Published
2025-05-19
DOI
https://doi.org/10.1186/s13059-025-03602-w
Citations
8
Primary Topic
Venomous Animal Envenomation and Studies
Type
article
Field-Weighted Citation Impact
14.54

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article

The gene regulatory mechanisms shaping the heterogeneity of venom production in the Cape coral snake

Daniel Petras, Eivind A. B. Undheim, Brett R. Hamilton, Paolo Stincone et al.
8 citations
Genome biology
Venomous Animal Envenomation and Studies
14.54
article

The gene regulatory mechanisms shaping the heterogeneity of venom production in the Cape coral snake

Daniel Petras, Eivind A. B. Undheim, Brett R. Hamilton, Paolo Stincone, Taline D. Kazandjian, Nicholas R. Casewell, Pedro G. Nachtigall
article en
8 citations

Abstract

Our results provide new insight into the variability of toxin regulation across snakes, reveal the molecular mechanisms underlying the heterogeneous toxin production in snake venom glands, and provide an example of how constraints can result in non-adaptive character states that appear to be adaptive, which may nevertheless facilitate evolutionary innovation and novelty.

Genome biologyVol. 26(1)
University of California, Riverside (US), The University of Queensland (AU), Liverpool School of Tropical Medicine (GB), University of Tübingen (DE)
Wellcome Trust, Universitetet i Oslo, European Research Council
Industry, innovation and infrastructure
Openalex Percentile: Top 1%
Venomous Animal Envenomation and Studies
14.54
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