Comparison of intravenous vs intravenous with step-down to oral antibiotic treatment course for Streptococcus and Enterococcus bloodstream infections

Oral step-down therapy was not associated with an increased risk of clinical failure compared to a full course of intravenous therapy for uncomplicated Streptococcus and Enterococcus bloodstream infections. Patients with more comorbidities or who required vasopressors were less likely to be switched to oral therapy.

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Publication Details

Journal
Antimicrobial Stewardship & Healthcare Epidemiology
Published
2025-01-01
DOI
https://doi.org/10.1017/ash.2025.168
Primary Topic
Streptococcal Infections and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparison of intravenous vs intravenous with step-down to oral antibiotic treatment course for Streptococcus and Enterococcus bloodstream infections

Nicole C. Nicolsen, Aaron M. Kipp, Kelsey Bouwman, Jacob Pierce et al.
Antimicrobial Stewardship & Healthcare Epidemiology
Streptococcal Infections and Treatments
article

Comparison of intravenous vs intravenous with step-down to oral antibiotic treatment course for Streptococcus and Enterococcus bloodstream infections

Nicole C. Nicolsen, Aaron M. Kipp, Kelsey Bouwman, Jacob Pierce, Alexandra Stang, Paul Vos, Jennifer Emberger
article en

Abstract

Oral step-down therapy was not associated with an increased risk of clinical failure compared to a full course of intravenous therapy for uncomplicated Streptococcus and Enterococcus bloodstream infections. Patients with more comorbidities or who required vasopressors were less likely to be switched to oral therapy.

Antimicrobial Stewardship & Healthcare EpidemiologyVol. 5(1)
East Carolina University (US)
Good health and well-being
Openalex Percentile: Top 85%
Streptococcal Infections and Treatments
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