Idiopathic normal pressure hydrocephalus: associations between CSF biomarkers, clinical symptoms, and outcome after shunt surgery
Axonal degeneration, as indicated by elevated NFL, is probably involved in the generation of the full iNPH tetrade of symptoms and tau pathology more specifically with iNPH cognitive impairment. No CSF biomarker could identify shunt responders. CSF evidence of Alzheimer pathology should not be used to exclude patients from shunt surgery.
Authors
- Anna Jeppsson (ORCID: https://orcid.org/0000-0002-5908-1904)
- Per Hellström (ORCID: https://orcid.org/0000-0001-9803-7271)
- Mats Tullberg (ORCID: https://orcid.org/0000-0003-4997-5266)
- Carsten Wikkelsø (ORCID: https://orcid.org/0000-0003-1720-7633)
- Kaj Blennow
- Henrik Zetterberg
- Majd Saadaldeen
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s12987-025-00661-w
- Citations
- 3
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- Göteborgs Universitet
- UK Dementia Research Institute
- HORIZON EUROPE Framework Programme