RNA polymerase I is essential for driving the formation of 3D genome in early embryonic development in mouse, but not in human
These observed interspecies distinctions in chromatin organization dynamics provide novel insights into the evolutionary divergence of chromatin architecture regulation during early mammalian development. Our findings provide mechanistic insights into species-specific chromatin organization during germ cell and embryonic development and have potential implications for fertility preservation and birth defect prevention.
Authors
- Bo Xu (ORCID: https://orcid.org/0000-0001-8693-3060)
- Yun Sun (ORCID: https://orcid.org/0000-0001-7990-822X)
- Xiaoming Teng
- Changliang Hou
- Jinfu Zhang (ORCID: https://orcid.org/0000-0002-0976-9583)
- Qian Fang (ORCID: https://orcid.org/0000-0001-8672-8200)
- Guoqing Tong
- Ping Yin
- Shuanggang Hu
- Beili Chen (ORCID: https://orcid.org/0000-0003-1359-1885)
- Ya Guo (ORCID: https://orcid.org/0000-0001-5350-266X)
- Rong Hu (ORCID: https://orcid.org/0000-0002-0009-2473)
- Ji Wu (ORCID: https://orcid.org/0000-0002-6424-9783)
- Guangxin Yao
- Zhaolian Wei (ORCID: https://orcid.org/0000-0001-8474-7272)
- Zhaoxia Wang (ORCID: https://orcid.org/0000-0002-1893-371X)
- Hao Chen (ORCID: https://orcid.org/0009-0001-6480-7976)
- Zhiguo Zhang (ORCID: https://orcid.org/0000-0003-1483-3321)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-5307-2484)
- Yuedi Cao
- Xiaoyong Li (ORCID: https://orcid.org/0009-0008-3199-6441)
- Geng Tian (ORCID: https://orcid.org/0000-0002-8807-5669)
- Yefan Wang (ORCID: https://orcid.org/0009-0003-3881-2071)
- Yunxia Cao
- Le Wei (ORCID: https://orcid.org/0000-0001-7194-6977)
- Man Zhang (ORCID: https://orcid.org/0000-0003-2985-3325)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- Chinese Academy of Sciences (CN)
- Nantong University (CN)
- Renji Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Institute of Biophysics (CN)
- Ministry of Education (KR)
- Ningxia Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Shuguang Hospital (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s13073-025-01476-y
- Citations
- 1
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- National Key Research and Development Program of China