Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma
This study identified promising histotype-specific biomarkers for EOC using integrative transcriptomic and epigenomic analysis. Furthermore, these findings indicate that additional stratification or potential reclassification of the EC histotype is warranted in future studies.
Authors
- Ella Ittner
- Toshima Z. Parris (ORCID: https://orcid.org/0000-0003-0834-5540)
- Claudia Mateoiu
- Elisabeth Werner Rönnerman
- Khalil Helou (ORCID: https://orcid.org/0000-0002-7847-4391)
- Lillian Werner (ORCID: https://orcid.org/0000-0002-9063-0457)
- Hugo Swenson
- Pernilla Dahm‐Kähler (ORCID: https://orcid.org/0000-0002-6699-893X)
- Szilárd Nemes (ORCID: https://orcid.org/0000-0002-4145-1786)
- Anikó Kovács (ORCID: https://orcid.org/0000-0001-8117-6283)
- Ghassan M. Saed (ORCID: https://orcid.org/0000-0003-1098-7147)
- Per Karlsson (ORCID: https://orcid.org/0000-0003-4841-2672)
Institutions
- Wayne State University (US)
- Sahlgrenska University Hospital (SE)
- Region Västra Götaland (SE)
- AstraZeneca (Sweden) (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1186/s13048-025-01676-5
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Cancerfonden
- Vetenskapsrådet
- Stiftelsen Assar Gabrielssons Fond
- Göteborgs Universitet
- Stiftelsen Jubileumsklinikens Forskningsfond mot Cancer