Neurosteroids, Anxiety and Quality of Life in Acromegaly

Abstract Objective Acromegaly reduces quality of life. Neurosteroids can impact neuropsychological status and anxiety, but their effects on anxiety in acromegaly cases and quality of life are unclear. This study aims to evaluate the relationship between neurosteroids, anxiety, and quality of life in acromegaly patients. Design This study included 33 cases in the acromegaly group (AG) and 30 healthy subjects in the control group (CG). Beck Anxiety Inventory (BAI) and Short Form-36 (SF-36) were used to assess anxiety levels and Quality of Life (QoL), respectively. The research assessed how anxiety and quality of life scores correlate with the concentrations of growth hormone, IGF-1, and specific neurosteroids (Allopregnanolone (AP), pregnenolone (PRG), 24S-hydroxycholesterol (24OHC), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androsterone (ADT)). Results AG had significantly higher BAI scores in comparison to CG. The SF-36 subdomain scores of general health, physical functioning, role limitations due to physical health, energy/fatigue, emotional well-being, social functioning, and pain were significantly lower in the AG. Conclusion Neurosteroids may affect the quality of life and be associated with depression and anxiety levels in acromegaly.